筑波大学 University of Tsukuba 国際統合睡眠医科学研究機構(WPI-IIIS)沓村・斉藤研究室 International Institute for Integrative Sleep Medicine (WPI-IIIS), Kutsumura・Saito Lab. 数理物質系化学域沓村研究室 Department of Chemistry, Faculty of Pure and Applied Sciences, Kutsumura Lab.

  • 筑波大学国際統合睡眠医科学研究機構
  • 独立行政法人 日本学術振興会
  • ムーンショット型研究開発事業

Welcome!

筑波大学数理物質系化学域沓村グループ(製薬化学)/国際統合睡眠医科学研究機構(WPI-IIIS)沓村・斉藤研究室(創薬化学)では、オレキシン受容体やオピオイド受容体に作用する新規化合物を設計・合成し、睡眠と覚醒の制御や痛みや鬱の治療など、主に中枢神経系に作用する薬物を標的とした創薬研究を行っています。

Kutsumura/Saito Laboratory(Medicinal Chemistry Group)designs and synthesizes novel compounds that act on the orexin receptors and opioid receptors and conducts drug discovery research targeting drugs that act primarily on the central nervoussystem, such as controlling sleep and wakefulness and treating pain and depression.

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November 24, 2022

Dr. Iio, a graduate student, and Ms. Amazawa (D3) made a  poster presentation at the 39th Symposium on Medicinal Chemistry (held online).

Date: November 23-25, 2022

Subject:Discovery of Novel Orexin Receptor Agonist with 1,3,5-Trioxazatriquinane Skeleton

Mao Amezawa,Tsuyoshi SaitohNaoshi Yamamoto,Yasuyuki Nagumo, Noriki Kutsumura, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase

Subject:Design and synthesis of selective orexin 1 receptor agonists

Keita Iio,Tsuyoshi SaitohKao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Yukiko Ishikawa, Naoshi Yamamoto, Noriki Kutsumura, Masashi Yanagisawa, Hiroshi Nagase

 

November 19, 2022

Ms. Amesawa (D3) and Mr. Kajino (D1) made a presentation at the 17th GPCR meeting (University of Tsukuba).

Date: November 18-19, 2022

Subject: Discovery of the Novel Chemical Library for GPCR Ligands Identification with1,3,5-Trioxazatriquinane Skeleton
Mao Amezawa,Tsuyoshi SaitohNaoshi Yamamoto,Yasuyuki Nagumo, Noriki Kutsumura, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase

Subject: Discovery of novel kappa opioid receptor agonists based on conformational regulation
Keita KajinoMasahiro Yata, Yasuyuki NagumoAkihisa Tokuda, Noriki Kutsumura, Tsuyoshi SaitohHiroshi Nagase


Mr. Kajino (D1)  gave an oral presentation at the 17th GPCR meeting (University of Tsukuba).

Date: November 19, 2022

Subject: Discovery of novel kappa opioid receptor agonists based on conformational regulation
Keita KajinoMasahiro Yata, Yasuyuki NagumoAkihisa Tokuda, Noriki Kutsumura, Tsuyoshi SaitohHiroshi Nagase

October 4, 2022

Ms.Amazawa (D3), Doctoral Program in Chemistry, received the Best Presentation Award (Oral) at the 66th Pharmaceutical Society of Japan Kanto Branch.

 

September 17, 2022
The 66th Pharmaceutical Society of Japan Kanto Branch
Mao Amazawa
Subject: Discovery of the Novel Orexin Receptor Agonist with 2-Methyl Tetralin Skeleton

September 23, 2022

Ms.Amezawa (D3) and Mr. Maeda (D2) gave an oral presentation at the 66th Pharmaceutical Society of Japan Kanto Branch ( Yokohama University of Pharmacy).
Date: September 23, 2022

 

Subject: 2-メチルテトラリン誘導体を用いたオレキシン受容体作動薬の開発
Mao Amezawa, Tsuyoshi Saitoh, Takahiro Okada, Ryuichiro Ohshita, Naoshi Yamamoto, Yasuyuki Nagumo, Noriki Kutsumura, Youko Irukayama, Yukiko Ishikawa , Masashi Yanagisawa, Hiroshi Nagase

 

Subject: 14-アミノナルトレキソン骨格の新奇転位反応と誘導体の薬理評価
Kenta Maeda, Akihisa Tokuda, Keita Kajino, Tsuyoshi Saitoh, Hiroshi Nagase, Noriki Kutsumura

September 1, 2022

Mr. Kajino (D1) gave an oral presentation at the 41st Symposium on Analgesics and Opioid Peptides (Held on demand).
Date: September 1-30, 2022
Subject: Discovery of novel kappa opioid receptor agonists based on conformational regulation
Keita Kajino, Yata Masahiro, Yasuyuki Nagumo, Akihisa Tokuda, Noriki Kutsumura, Tsuyoshi Saitoh, Hiroshi Nagase

June 13, 2022

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library
Saitoh, T.Amezawa, M.Horiuchi, J.Nagumo, Y.Yamamoto, N.Kutsumura, N.Ohshita, R.Tokuda, A.; Irukayama-Tomobe, Y.; Ogawa, Y.; Ishikawa, Y.; Hasegawa, E.; Sakurai, T.; Uchida, Y.; Sato, T.; Gouda, H.; Tanimura, R.; Yanagisawa, M.; Nagase, H.

Eur. J. Med. Chem.2022, 240, 114505. (web)

 

May 21, 2022

Mr. Maeda (D1) gave an oral presentation at the 82nd Symposium of Kanto Branch, The Society of Synthetic Organic Chemistry, Japan (Yokohama National University, Jobandai Campus).

Date: May 21, 2022
Subject: Novel rearrangement reactions of 14-aminonaltrexone skeleton
Kenta Maeda, Hiroshi Nagase, Noriki Kutsumura

April 1,2022

Mr. Keita Iio, Dean’s Award (Doctral Program)
Research Title: Design and Synthesis of Orexin Receptor Agonists with a Tetralin Skeleton and MRGPRX2 Agonists with a Morphinan Skeleton

April 1, 2020

FY 2020 has been started with new members!

July 12, 2018

Prof. Nagase gave a lecture at Japanese Society of Sleep Research The 43rd Annual Meeting(JSSR43).
Date:8:30~10:30  July 12, 2018
Title:睡眠覚醒を標的とする創薬研究
Venue:Sapporo Convention Center
Title:オピオイド受容体を標的とする創薬

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