筑波大学 University of Tsukuba 国際統合睡眠医科学研究機構(WPI-IIIS)沓村・斉藤研究室 International Institute for Integrative Sleep Medicine (WPI-IIIS), Kutsumura・Saito Lab. 数理物質系化学域沓村研究室 Department of Chemistry, Faculty of Pure and Applied Sciences, Kutsumura Lab.

  • 筑波大学国際統合睡眠医科学研究機構
  • 独立行政法人 日本学術振興会
  • ムーンショット型研究開発事業

Welcome!

筑波大学数理物質系化学域沓村グループ(製薬化学)/国際統合睡眠医科学研究機構(WPI-IIIS)沓村・斉藤研究室(創薬化学)では、オレキシン受容体やオピオイド受容体に作用する新規化合物を設計・合成し、睡眠と覚醒の制御や痛みや鬱の治療など、主に中枢神経系に作用する薬物を標的とした創薬研究を行っています。

Kutsumura/Saito Laboratory(Medicinal Chemistry Group)designs and synthesizes novel compounds that act on the orexin receptors and opioid receptors and conducts drug discovery research targeting drugs that act primarily on the central nervoussystem, such as controlling sleep and wakefulness and treating pain and depression.

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English

September 11, 2023

第53回日本神経精神薬理学会年会 

A poster presentation

■Subject: 新規創製選択的オレキシン1受容体作動薬の鎮痛効果と疼痛モデルマウスにおける治療有効性の解析

Kao Hashimoto, Yasuyuki Nagumo, Keita Iio,Taisei Hasegawa, Akihisa Tokuda, Hikari Yamamoto, Yasuo Uchida,  Noriki Kutsumura, Masashi Yanagisawa, Tsuyoshi Saitoh, Hiroshi Nagase

July 2, 2023

Associate Prof.Tsuyoshi Saitoh delivered an invited lecture, and Mr. Keita Kajino(D2) and Mr.Rintaro Otani(M2) gave a poster presentation at the 56th Natural Products Chemistry Colloquium.

Date: June 29-30, 2023
Venue: Tsukuba International Congress Center

 

Subject:Re:ゼロから始めるメドケム研究( 発表者:斉藤 毅)
Subject:モルヒナン骨格を有するκオピオイド受容体選択的作動薬の創出(ポスター発表:梶野景太)
Subject: アデノシン2A受容体を標的とする光ケージド薬物の開発(ポスター発表:大谷凛太郎)

April 24, 2023

The following three students received the Best Student Presentation Award at the 143rd Annual Meeting of the Pharmaceutical Society of Japan.

Mr. Tomoya Kakumoto (B4)
Subject: δオピオイド受容体作動薬の副作用分離を目指した新規モルヒナン誘導体の合成と評価
Mr. Keita Kajino (D1)
Subject: ヘテロビシクロ[2.2.2]オクタン骨格を有する新規κオピオイド受容体作動薬の創製
Ms. Kao Hashimoto (D1)
Subject: オレキシン1受容体を介する疼痛制御メカニズムの解析

 

March 24, 2023

Ms. Amazawa (D3), Doctoral Program in Chemistry, awarded Dean’s Award (Doctral Program) from the Univ. of Tsukuba.
Research Title: Design and Synthesis of the Novel Orexin Receptor Ligands with 1,3,5-Trioxazatriquinane Skeleton

February 22, 2023

Mr. Otani (M1), Mr. Kajino (D1), and Ms. Hashimoto (D1) made a poster presentation at The 11th Annual WPI-IIIS Symposium.

 

Date: February 22, 2023

 

■Subject: Analysis of orexinergic function in chronic pain-like states
Kao Hashimoto, Yasuyuki Nagumo, Keita Iio, Yuki Saito, Yukiko Ishikawa, Noriki Kutsumura, Takeshi Sakurai, Masashi Yanagisawa, Tsuyoshi Saitoh, Hiroshi Nagase

■Subject: Design and synthesis of novel κ opioid receptor agonists with bicyclo [2.2.2] octene skeleton
Keita Kajino, Masahiro Yata, Yasuyuki Nagumo, Akihisa Tokuda, Noriki Kutsumura, Tsuyoshi Saitoh, Hiroshi Nagase

■Subject: Development of photocaged drugs targeting adenosine 2A receptor
Rintaro Otani, Shuji Ioka, Mustafa Korkutata, Yohei Chitose, Manabu Abe, Michael Lazarus, Tsuyoshi Saitoh

January 30, 2023

The lectures were given by Dr. Hiroshi Nagase, University of Tsukuba, and Dr. Ryoji Suno, Kansai Medical University.

Date: Jan 27, 2023

Venue: IIIS Building

 

November 24, 2022

Dr. Iio, a graduate student, and Ms. Amazawa (D3) made a  poster presentation at the 39th Symposium on Medicinal Chemistry (held online).

Date: November 23-25, 2022

Subject:Discovery of Novel Orexin Receptor Agonist with 1,3,5-Trioxazatriquinane Skeleton

Mao Amezawa,Tsuyoshi SaitohNaoshi Yamamoto,Yasuyuki Nagumo, Noriki Kutsumura, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase

Subject:Design and synthesis of selective orexin 1 receptor agonists

Keita Iio,Tsuyoshi SaitohKao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Yukiko Ishikawa, Naoshi Yamamoto, Noriki Kutsumura, Masashi Yanagisawa, Hiroshi Nagase

 

November 19, 2022

Ms. Amesawa (D3) and Mr. Kajino (D1) made a presentation at the 17th GPCR meeting (University of Tsukuba).

Date: November 18-19, 2022

Subject: Discovery of the Novel Chemical Library for GPCR Ligands Identification with1,3,5-Trioxazatriquinane Skeleton
Mao Amezawa,Tsuyoshi SaitohNaoshi Yamamoto,Yasuyuki Nagumo, Noriki Kutsumura, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase

Subject: Discovery of novel kappa opioid receptor agonists based on conformational regulation
Keita KajinoMasahiro Yata, Yasuyuki NagumoAkihisa Tokuda, Noriki Kutsumura, Tsuyoshi SaitohHiroshi Nagase


Mr. Kajino (D1)  gave an oral presentation at the 17th GPCR meeting (University of Tsukuba).

Date: November 19, 2022

Subject: Discovery of novel kappa opioid receptor agonists based on conformational regulation
Keita KajinoMasahiro Yata, Yasuyuki NagumoAkihisa Tokuda, Noriki Kutsumura, Tsuyoshi SaitohHiroshi Nagase

October 4, 2022

Ms.Amazawa (D3), Doctoral Program in Chemistry, received the Best Presentation Award (Oral) at the 66th Pharmaceutical Society of Japan Kanto Branch.

 

September 17, 2022
The 66th Pharmaceutical Society of Japan Kanto Branch
Mao Amazawa
Subject: Discovery of the Novel Orexin Receptor Agonist with 2-Methyl Tetralin Skeleton

September 23, 2022

Ms.Amezawa (D3) and Mr. Maeda (D2) gave an oral presentation at the 66th Pharmaceutical Society of Japan Kanto Branch ( Yokohama University of Pharmacy).
Date: September 23, 2022

 

Subject: 2-メチルテトラリン誘導体を用いたオレキシン受容体作動薬の開発
Mao Amezawa, Tsuyoshi Saitoh, Takahiro Okada, Ryuichiro Ohshita, Naoshi Yamamoto, Yasuyuki Nagumo, Noriki Kutsumura, Youko Irukayama, Yukiko Ishikawa , Masashi Yanagisawa, Hiroshi Nagase

 

Subject: 14-アミノナルトレキソン骨格の新奇転位反応と誘導体の薬理評価
Kenta Maeda, Akihisa Tokuda, Keita Kajino, Tsuyoshi Saitoh, Hiroshi Nagase, Noriki Kutsumura

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