We are engaged in the design and synthesis of orexin receptor agonists,
and also opioid research in WPI-IIIS, University of Tsukuba.

Nov. 1, 2014

Prof. Nagase was featured in the Pain Clinic.

ペインクリニック <月刊> 11月号 Vol.35 No.11 ……………… 真興交易医書出版部

●総説
難治性掻痒症治療薬ナルフラフィンの創出と痒み調節機構の解明 …長瀬 博

Pain35-11-11

Oct. 20, 2014

Graduate School Application Information

<Majors of Medical Sciences, Comprehensive Human Sciences>

Japanese:http://www.md.tsukuba.ac.jp/gradmed/exam/

English:http://www.md.tsukuba.ac.jp/gradmed/en/exam/

Oct. 16, 2014

Watanlabe, Y.; Kitazawa, S.; Fujii, H.; Nemoto, T.; Hirayama, S.; Iwai, T.; Gouda, H.; Hirono, S.; Nagase, H.

Full-size image (22 K)

“Design, synthesis, and structure–activity relationship of novel opioid κ receptor selective agonists: α-Iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton”

Bioorg. Med. Chem. Lett. 201424, 4980–4983. (web)

Oct. 6, 2014

Shigeto Hirayamaa, Naohisa Wadaa, Naoya Kurodaa, Takashi Iwaia, Noriyuki Yamaotsua, Shuichi Hironoa, Hideaki Fujiia, Hiroshi Nagase

Full-size image (16 K)

“Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies”
Bioorg. Med. Chem. Lett. 2014, 24, 4895–4898.(web)

Sep. 24, 2014

Dr. Saitoh gave a lecture at DPhG Jahrestagung 2014.

Title 「Design and synthesis of NF-kB inhibitors carring epoxyquinol moiety」

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We are engaged in the design and synthesis of orexin receptor agonists, and also opioid research in WPI-IIIS, University of Tsukuba.

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