We are engaged in the design and synthesis of orexin receptor agonists,
and also opioid research in WPI-IIIS, University of Tsukuba.

University of Tsukuba, International Institute for Integrative Sleep Medicine (WPI-IIIS)Nagase Laboratory (Medicinal Chemistry)

Apr. 2013: Watanabe, Y.; Kitazawa, S.; Nemoto, T.; Hirayama, S.; Iwai, T.; Fujii, H.; Nagase, H.*
“Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies”
Bioorg. Med. Chem. 2013, 21, 3032-3050.
May 2013: Kutsumura, N.*; Matsubara, Y.; Niwa, K.; Ito, A.; Saito, T.*
“One-Pot Method for Regioselective Bromination and Sequential Carbon−Carbon Bond-Forming Reactions of Allylic Alcohol Derivatives”
Eur. J. Org. Chem. 2013, 3337-3346.
Apr. 2013: Wine Party for New Laboratory!
Apr. 2013: Our group was started!!