We are engaged in the design and synthesis of orexin receptor agonists,
and also opioid research in WPI-IIIS, University of Tsukuba.

Dec. 15-20, 2015

Mr.Nakajima(D3) made a presentation at PACIFICHEM2015.

Title :Synthesis of novel pentacyclic derivatives with propellane skeleton and their structure-activity relationships
7:00pm – 9:00pm Fri, Dec 18
Halls I, II, III – Hawaii Convention Center

Dec. 15-20, 2015

Dr.Saitoh made a presentation at PACIFICHEM2015.
Title :Electrochemical reduction by means of boron-doped diamond electrode
1:30pm – 1:55pm Tue, Dec 15
322AB – Hawaii Convention Center

 

Title :Discovery of novel orexin receptor agonists for controlling sleep/awake cycle
11:10am – 11:20am Sat, Dec 19
Tapa Tower, Tapa Ballrm 3 – Hilton Hawaiian Village

Dec. 15-20, 2015

Prof. Nagase made a presentation at PACIFICHEM2015.
Title :Design and synthesis of novel ligands of opioid receptors
1:40pm – 2:10pm  Thu, Dec 17
Tapa Tower, Tapa Ballrm 3 – Hilton Hawaiian Village

Nov. 6, 2015

Discovery of a novel compound regulating wakefulness

Hiroshi Nagase (core PI of IIIS) and his research group, in collaboration with Masashi Yanagisawa, successfully discovered the potent orexin agonist which shows nearly equivalent effect with endogenous orexin and effective in improving narcoleptic symptoms in mice. Their achievement is an important first step to develop an entirely novel drug for the remedy of narcolepsy. This landmark paper was published in the October issue of Journal of Medicinal Chemistry.

Press release

Link to article

Nov. 4, 2015

T. Nagahara, T. SaitohN. Kutsumura, Y. Irukayama-Tomobe, Y. Ogawa, D.

Kuroda, H. Gouda, H. Kumagai, H. Fujii, M. Yanagisawa, H. Nagase

“Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists“

J. Med. Chem. 201558, 7931-7937. (web)

jm-2015-00988p_0012

 

Nov. 27, 2015

Dr.Kutsumura gave a lecture at Community of Bromine Application (Japanese only).

Nov. 25-27, 2015

Dr.Yamamoto, Dr.Saitoh, Mr.Ohshita(M2) and Mr.Okada(M2) had a presentation at Medicinal Chemistry Symposium 2015.

Oct. 26-27, 2015

Mr.Ohshita(M2) and Mr.Okada(M2) did a presentation at 41th symposium on progress in organic reactions and syntheses (Japanese only).

Oct. 19, 2015

Mr.Koyama(M2) won a Excellent Subject Awards!

Oct. 16-17, 2015

Mr.Koyama(M2) and Mr.Okada(M2) did a presentation at 35th Annual Meeting of JNRC.

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We are engaged in the design and synthesis of orexin receptor agonists, and also opioid research in WPI-IIIS, University of Tsukuba.

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