We are engaged in the design and synthesis of orexin receptor agonists,
and also opioid research in WPI-IIIS, University of Tsukuba.

Dec 6, 2016

“Desiagn and Synthesis of non-peptidic orexin 2 agonists” (Prof. Nagase) was published in Igaku No Ayumi Vol.259 No.2.

Nov 30-Dec 2, 2016

Dr. Saitoh, Ms. Ohrui(D2), Mr. Koyama(D1)Mr. Yata(M2) and Mr. Seki(M2)  will make a presentation at The MCS2016 (Medicinal Chemistry Symposium 2016) .

Nov 26-27, 2016

Mr.Ohshita(D1)Mr.Horiuchi(M1) and Ms.Suzuki(M1) made a presentation at Niigata Sympoium (Japanese only).

Nov 14-16, 2016

Mr.Ohshita(D1) and Mr.Horiuchi(M1) made a presentation at The 6th CSJ Chemistry Festa (Japanese only).

Nov 7-8, 2016

Dr. Saitoh, Mr.ZHANG(D2) and Mr.Koyama(D1) made a presentation at 42th symposium on progress in organic reactions and syntheses (Japanese only).

Nov 4, 2016

CONFERENCE PRESENTATION FOR NC-2800, AN ANTIDEPRESSANT/ANXIOLYTIC DRUG CANDIDATE TARGETING δ OPIOID RECEPTORS

International Institute for Integrative Sleep Medicine, University of Tsukuba, Kitasato University, National Center of Neurology and Psychiatry and Nippon Chemiphar Co., Ltd. have been proceeding with joint research for a selective δ opioid receptor (DOR) agonist (NC-2800) with support from Japan Agency for Medical Research and Development (AMED).

This time, as the result of this joint research, we have found that NC-2800 shows excellent and rapid antidepressant-like effects at low dose levels, in an animal model of depression which requires long term treatment before obtaining therapeutic effects with existent antidepressants. We are going to present the results at the Society for Neuroscience annual meeting 2016 to be held in San Diego, USA, from November 12 to 16, 2016

Details of the presentation

【Title】 A novel δ opioid receptor agonist NC-2800 produces anxiolyticlike and antidepressant-like effects in animal models.

【Presenter】  Akiyoshi Saitoh1 (Speaker), Eriko Nakata2 , Leo Gotoh1 , Masaaki Hirose2 , Junichi Sakai2 , Takao Komatsu2 , Hideaki Fujii3 , Mitsuhiko Yamada1 , Hiroshi Nagase4 , Tomio Yamakawa2

【Poster Number】 71.09 VV6

【Date of presentation】 November 12, 2016, 13:00-17:00 (local time)

Nov 2, 2016

Prof. Nagase gave a lecture at  ONO PHARMACEUTICAL CO., LTD.

Nov 1, 2016

Dr. Saitoh gave a lecture at  The kitasato university school of pharmacy.

Oct 31 2016

Akiyoshi Saitoh, Hiroshi Nagase

“Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept”

Springer, Handbook of Experimental Pharmacology pp 1-17.

DOI:10.1007/164_2016_18

Oct 20 2016

Prof. Nagase gave a lecture at  厚木市皮膚科医会講演会.

Date  :2016/10/20  19:15~20:15

Venue  :REMBRANDT HOTEL ATSUGI

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We are engaged in the design and synthesis of orexin receptor agonists, and also opioid research in WPI-IIIS, University of Tsukuba.

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