We are engaged in the design and synthesis of orexin receptor agonists,
and also opioid research in WPI-IIIS, University of Tsukuba.

July. 13, 2017

Kutsumura, N.Ohshita, R.Horiuchi, J.; Tateno, K.; Yamamoto, N.Saitoh, T.Nagumo, Y.; Kawai, H.; Nagase, H.
“Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon”
Tetrahedron 2017, in press.
DOI: 10.1016/j.tet.2017.07.016

July. 3, 2017

Yamamoto, N.Ohrui, S.Okada, T.Yata, M.Saitoh, T.Kutsumura, N.Nagumo, Y.; Irukayama-Tomobe, Y.; Ogawa, Y.; Ishikawa, Y.; Watanabe, Y.; Hayakawa, D.; Gouda, H.; Yanagisawa, M.; Nagase, H.
“Essential structure of orexin 1 receptor antagonist YNT-707: Part I role of the 4,5-epoxy ring for binding with orexin 1 receptor”
Bioorg. Med. Chem. Lett. 2017, in press.
DOI: 10.1016/j.bmcl.2017.07.011

July. 4, 2017

Mr.Ohshita(D2) received a Poster Award from The 6th JACI/GSCN symposium.

July. 10, 2017

Mr.Yata(D1) made a presentation at The International Narcotics Research Conference 2017.

Title:Design and synthesis a novel κ opioid receptor agonists isolating both sedation and aversion.

Venue:Hyatt Centric Chicago Magnificent Mile

July. 5, 2017

Prof. Nagase gave a lecture at  The Graduate School of Life Science in Hokkaido University.

July. 4, 2017

Mr.Ohshita(D2) made a presentation at JACI/GSC symposium.

June. 26, 2017

N. KutsumuraY. KoyamaY. NagumoR. Nakajima, Y. Miyata, N. YamamotoT. Saitoh, N. Yoshida, S. Iwata, H. Nagase
“Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives”
Bioorg. Med. Chem. 2017, in press.
DOI: 10.1016/j.bmc.2017.06.026

June. 24, 2017

Prof. Nagase gave a lecture at  Juntendo University Institute for Environmental and Gender-Specific Medicine.

June. 20, 2017

Prof. Nagase gave a lecture at  TECHNICAL INFORMATION INSTITUTE CO.,LTD..

Date  :2017/6/20

http://www.gijutu.co.jp/doc/s_604103.htm

Apr. 5, 2017

Prof. Nagase was selected for Marquis Who’s Who 2017 Albert Nelson Marquis Lifetime Achievement Award

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We are engaged in the design and synthesis of orexin receptor agonists, and also opioid research in WPI-IIIS, University of Tsukuba.

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