筑波大学WPI-IIIS長瀬研究室(創薬化学)では、オレキシン作動薬の開発やオピオイドの研究を行っています。

2017 Original Papers / 2017 原著論文

  1. Kutsumura, N.; Shibuya, K.; Yamaguchi, H.; Saito, T.
    n-Butyllithium-promoted regioselective elimination of vicinal bis-triflate having an adjacent ether oxygen”
    Tetrahedron Lett. 2017, in press. (web)
  2. Yamamoto, N.; Okada, T.; Harada, Y.; Kutsumura, N.; Imaide, S.; Saitoh, T.; Fujii, H.; Nagase, H.
    “The application of a specific morphinan template to the synthesis of galanthamine”
    Tetrahedron 2017, 73, 5751-5758. (web)
  3. Fujii, H.; Shimada, N.; Ohtawa, M.; Karaki, F.; Koshizuka, M.; Hayashida, K.; Kamimura, M.; Makino, K.; Nagamitsu, T.; Nagase, H.
    “Deprotection of silyl ethers by using SO3H silica gel: Application to sugar, nucleoside, and alkaloid derivatives”
    Tetrahedron 2017, 73, 5425-5429. (web)
  4. Kutsumura, N.; Ohshita, R.; Horiuchi, J.; Tateno, K.; Yamamoto, N.; Saitoh, T.; Nagumo, Y.; Kawai, H.; Nagase, H.
    “Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon”
    Tetrahedron 2017, 73, 5214-5219. (web)
  5. Yamamoto, N.; Ohrui, S.; Okada, T.; Yata, M.; Saitoh, T.; Kutsumura, N.; Nagumo, Y.; Irukayama-Tomobe, Y.; Ogawa, Y.; Ishikawa, Y.; Watanabe, Y.; Hayakawa, D.; Gouda, H.; Yanagisawa, M.; Nagase, H.
    “Essential structure of orexin 1 receptor antagonist YNT-707: Part I Role of the 4,5-epoxy ring for binding with orexin 1 receptor”
    Bioorg. Med. Chem. Lett. 2017, 27, 4176-4179. (web)
  6. Kutsumura, N.; Koyama, Y.; Nagumo, Y.; Nakajima, R.; Miyata, Y.; Yamamoto, N.; Saitoh, T.; Yoshida, N.; Iwata, S.; Nagase, H.
    “Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives”
    Bioorg. Med. Chem. 2017, 25, 4375-4383. (web)
  7. Watanabe, Y.; Hayashida, K.; Saito, D.; Takahashi, T.; Sakai, J.; Nakata, E.; Kanda, T.; Iwai, T.; Hirayama, S.; Fujii, H.; Yamakawa, T.; Nagase, H.
    “Design and synthesis of novel δ opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration”
    Bioorg. Med. Chem. Lett. 2017, 27, 3495-3498. (web)
  8. Hayashida, K.; Hirayama, S.; Iwai, T.; Watanabe, Y.; Takahashi, T.; Sakai, J.; Nakata, E.; Yamakawa, T.; Fujii, H.; Nagase, H.
    “Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities”
    Bioorg. Med. Chem. Lett. 2017, 27, 2742-2745. (web)
  9. Irukayama-Tomobe, Y.; Ogawa, Y.; Tominaga, H.; Ishikawa, Y.; Hosokawa, N.; Ambai, S.; Kawabe, Y.; Uchida, S.; Nakajima, R.; Saitoh, T.; Kanda, T.; Vogt, K.; Sakurai, T.; Nagase, H.; Yanagisawa, M.
    “Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models”
    Proc. Nat. Acad. Sci. USA 2017, 114, 5731-5736. (web)
  10. Hamada, Y.; Tasaki, Y.; Morita, K.; Yamamizu, K.; Narita, M.; Matsuyama, F.; Suzuki, M.; Ikegami, D.; Arakawa, K.; Nagumo, Y.; Kawata, M.; Uezono, Y.; Nagase, H.; Aoki, K.; Yamashita, J. K.; Kuzumaki, N.; Narita, M.
    “The κ-Opioid Receptor Agonist Nalfurafine Enhances the Chemotherapy-induced Survival Advantage in Pancreatic Cancer-bearing Mice”
    Jpn. J. Pharm. Palliat. Care Sci. 2017, 10, 7-12.
  11. Lansu, K.; Karpiak, J.; Liu, J.; Huang, X.-P.; McCorvy, J. D.; Kroeze, W. K.; Che, T.; Nagase, H.; Carroll, F. I.; Jin, J.; Shoichet, B. K.; Roth, B. L.
    In silico design of novel probes for the atypical opioid receptor MRGPRX2″
    Nat. Chem. Biol. 2017, 13, 529-536. (web)
  12. Nagase, H.; Yamamoto, N.; Yata, M.; Ohrui, S.; Okada, T.; Saitoh, T.; Kutsumura, N.; Nagumo, Y.; Irukayama-Tomobe, Y.; Ishikawa, Y.; Ogawa, Y.; Hirayama, S.; Kuroda, D.; Watanabe, Y.; Gouda, H.; Yanagisawa, Y.
    “Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and their Pharmacologies”
    J. Med. Chem. 201760, 1018-1040. (web)
  13. Gotoh, L.; Saitoh, A.; Yamada, M.; Fujii, H.; Nagase, H.; Yamada, M.
    “Effects of repeated treatment with a delta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats”
    Behav. Brain Res. 2017, 323, 11-14. (web)

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筑波大学WPI-IIIS長瀬研究室(創薬化学)では、オレキシン作動薬の開発や、オピオイドの研究を行っています。

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