“saitoh”で検索した結果、53件の記事が見つかりました。
2024 Original Papers / 2024 原著論文
- Maeda, K.; Sugai, T.; Tokuda, A.; Kajino, K.; Saitoh, T.; Nagase, H.; Kutsumura, N.
“Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands”
Bioorg. Med. Chem. Lett. 2024, 99, 129611. (web)
2023 Original Papers / 2023 原著論文
- Kawaminami, A.; Yamada, D.; Yoshioka, T.; Hatakeyama, A.; Nishida, M.; Kajino, K.; Saitoh, T.; Nagase, H.; Saitoh, A.
“The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala”
Neuropsychopharmacol. Rep. 2023, in press. (web) - Maeda, K.; Ohrui, S.; Tokuda, A.; Nagumo, Y.; Yamamoto, N.; Tanimura, R.; Saitoh, T.; Kutsumura, N.; Nagase, H.
“Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton”
Org. Lett. 2023, 25, 3407-3411. (web) - Lin, Y.; Roy, K.; Ioka, S.; Otani, R.; Amezawa, M.; Ishikawa, Y.; Cherasse, Y.; Kaushik, M. K.; Klewe-Nebenius, D.; Zhou, L.; Yanagisawa, M.; Oishi, Y.; Saitoh, T.; Lazarus, M.
“Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice”
Front. Pharmacol. 2023, 14, 1138666. (web) - Iio, K.; Hashimoto, K.; Nagumo, Y.; Amezawa, M.; Hasegawa, T.; Yamamoto, N.; Kutsumura, N.; Takeuchi, K.; Ishikawa, Y.; Yamamoto, H.; Tokuda, A.; Sato, T.; Uchida, Y.; Inoue, A.; Tanimura, R.; Yanagisawa, M.; Nagase, H.; Saitoh, T.
“Design and Synthesis of Orexin 1 Receptor-Selective Agonists”
J. Med. Chem. 2023, 66, 5453-5464. (web) - Amezawa, M.; Yamamoto, N.; Nagumo, Y.; Kutsumura, N.; Ishikawa, Y.; Yanagisawa, M.; Nagase, H.; Saitoh, T.
“Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton”
Bioorg. Med. Chem. Lett. 2023, 82, 129151. (web)
2022 Original Papers / 2022 原著論文
- Yamamoto, H.; Nagumo, Y.; Ishikawa, Y.; Irukayama-Tomobe, Y.; Namekawa, Y.; Nemoto, T.; Tanaka, H.; Takahashi, G.; Tokuda, A.; Saitoh, T.; Nagase, H.; Funato, H.; Yanagisawa, M.
“OX2R-selective orexin agonism is sufficient to amelioratecataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy”
PLOS ONE 2022, 17, e0271901. (web) - Kitano, M.; Saitoh, T.; Nishiyama, S.; Einaga, Y.; Yamamoto, T.
“Electro-conversion of cumene into acetophenone using boron-doped diamond electrodes”
Beilstein J. Org. Chem. 2022, 18, 1154-1158. (web) - Saitoh, T.; Amezawa, M.; Horiuchi, J.; Nagumo, Y.; Yamamoto, N.; Kutsumura, N.; Ohshita, R.; Tokuda, A.; Irukayama-Tomobe, Y.; Ogawa, Y.; Ishikawa, Y.; Hasegawa, E.; Sakurai, T.; Uchida, Y.; Sato, T.; Gouda, H.; Tanimura, R.; Yanagisawa, M.; Nagase, H.
“Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library“
Eur. J. Med. Chem. 2022, 240, 114505. (web) - Kawaminami, A.; Yamada, D.; Yanagisawa, S.; Shirakata, M.; Iio, K.; Nagase, H.; Saitoh, A.
“Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice”
Front. Behav. Neurosci. 2022, 16, 808232. (web) - Yamauchi, T.; Yoshioka, T.; Yamada, D.; Hamano, T.; Ohashi, M.; Matsumoto, M.; Iio, K.; Ikeda, M.; Kamei, M.; Otsuki, T.; Sato, Y.; Nii, K.; Suzuki, M.; Ichikawa, H.; Nagase, H.; Iriyama, S.; Yoshizawa, K.; Nishino, S.; Miyazaki, S.; Saitoh, A.
“Cold-Restraint Stress-Induced Ultrasonic Vocalization as a Novel Tool to Measure Anxiety in Mice”
Biol. Pharm. Bull. 2022, 45, 268-275. (web) - Iio, K.; Saitoh, T.; Ohshita, R.; Hino, T.; Amezawa, M.; Takayama, Y.; Nagumo, Y.; Yamamoto, N.; Kutsumura, N.; Irukayama-Tomobe, Y.; Ishikawa, Y.; Tanimura, R.; Yanagisawa, M.; Nagase, H.
“Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring”
Bioorg. Med. Chem. Lett. 2022, 60, 128555. (web) - Katoh, K.; Kutsumura, N.; Yamamoto, N.; Nagumo, Y.; Saitoh, T.; Ishikawa, Y.; Irukayama-Tomobe, Y.; Tanimura, R.; Yanagisawa, M.; Nagase, H.
“Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in D-nor-nalfurafine derivatives”
Bioorg. Med. Chem. Lett. 2022, 59, 128550. (web) - Hino, T.; Saitoh, T.; Nagumo, Y.; Yamamoto, N.; Kutsumura, N.; Irukayama-Tomobe, Y.; Ishikawa, Y.; Tanimura, R.; Yanagisawa, M.; Nagase, H.
“Design and synhtesis of novel orexin 2 receptor agonists based on naphthalene skeleton”
Bioorg. Med. Chem. Lett. 2022, 59, 128530. (web) - Katoh, K.; Yamamoto, N.; Ishikawa, Y.; Irukayama-Tomobe, Y.; Tanimura, R.; Saitoh, T.; Nagumo, Y.; Kutsumura, N.; Yanagisawa, M.; Nagase, H.
“Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors”
Bioorg. Med. Chem. Lett. 2022, 59, 128527. (web) - Iio, K.; Kutsumura, N.; Nagumo, Y.; Saitoh, T.; Tokuda, A.; Hashimoto, K.; Yamamoto, N.; Kise, R.; Inoue, A.; Mizoguchi, H.; Nagase, H.
“Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands”
Bioorg. Med. Chem. Lett. 2022, 56, 128485. (web)
2021 Original Papers / 2021 原著論文
- Hino, T.; Kutsumura, N.; Saitoh, T.; Yamamoto, N.; Nagumo, Y.; Mogi, Y.; Watanabe, Y.; Nagase, H.
“Novel Baeyer-Villiger-type oxidation of 4,5-epoxymorphinan derivatives”
Tetrahedron Lett. 2021, 63, 152714. (web)
2020 Original Papers / 2020 原著論文
- Nagumo, Y.; Ueta, Y.; Nakayama, H.; Osaki, H.; Takeuchi, Y.; Uesaka, N.; Kano, M.; Miyata, M.
“Tonic GABAergic inhibition is essential for nerve injury-induced afferent remodeling in the somatosensory thalamus and ectopic sensations”
Cell Reports 2020, 31, 107797. (web) - Nagumo, Y.; Katoh, K.; Iio, K.; Saitoh, T.; Kutsumura, N.; Yamamoto, N.; Ishikawa, Y.; Irukayama-Tomobe, Y.; Ogawa, Y.; Baba, T.; Tanimura, R.; Yanagisawa, M.; Nagase, H.
“Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine”
Bioorg. Med. Chem. Lett. 2020, 30, 127360. (web) - Kutsumura, N.; Koyama, Y.; Saitoh, T.; Yamamoto, N.; Nagumo, Y.; Miyata, Y.; Hokari, R.; Ishiyama, A.; Iwatsuki, M.; Otoguro, K.; Ōmura, S.; Nagase, H.
“Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities”
Molecules 2020, 25, 1112. (web) (Invited Paper) - Saitoh, T.; Seki, K.; Nakajima, R.; Yamamoto, N.; Kutsumura, N.; Nagumo, Y.; Irukayama-Tomobe, Y.; Ogawa, Y.; Ishikawa, Y.; Yanagisawa, M.; Nagase, H.
“Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group”
Bioorg. Med. Chem. Lett. 2020, 30, 126893. (web)