筑波大学WPI-IIIS長瀬研究室(創薬化学)では、オレキシン作動薬の開発やオピオイドの研究を行っています。

2011 Original Papers / 2011 原著論文

  1. Kutsumura, N.; Iijima, M.; Toguchi, S.; Saito, T.
    1,8-Diazabicyclo[5.4.0]undec-7-ene-promoted Regioselective Elimination of Vicinal Dibromides Having an Adjacent O- and/or N-Functional Group
    Chem. Lett. 2011, 40, 1231-1232.
  2. Kutsumura, N.; Kunimatsu, S.; Kagawa, K.; Otani, T.; Saito, T.
    Synthesis of Benzimidazole-Fused Heterocycles by Intramolecular Oxidative C–N Bond Formation Using Hypervalent Iodine Reagents
    Synthesis 2011, 3235-3240.
  3. Yamamoto, N.; Fujii, H.; Nemoto, T.; Nakajima, R.; Momen, S.; Izumimoto, N.; Hasebe, K.; Mochizuki, H.; Nagase, H.
    Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: Part 1
    Bioorg. Med. Chem. Lett. 2011, 21, 4104-4107.
  4. Kutsumura, N.; Kubokawa, K.; Saito, T.
    TBAF-Promoted Elimination of Vicinal Dibromides Having an Adjacent O-Functional Group: Syntheses of 2-Bromoalk-1-enes and Alkynes
    Synthesis 2011, 2377-2382.
  5. Saitoh, A.; Sugiyama, A.; Yamada, M.; Inagaki, M.; Oka, J.; Nagase, H.; Yamada, M.
    The novel κ opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepines
    Behavioral Brain Research 1, 2011, 223, 271-279.
  6. Saitoh, T.; Takeiri, M.; Gotoh, Y.; Ishikawa, Y.; Umezawa, K.; Nishiyama, S.
    Design and synthesis of biotinylated for direct identification of its target NF-κB components
    Bioorg. Med. Chem. Lett. 2011, 21, 6293-6296.
  7. Smith, A. B., III; Kutsumura, N.; Potuzak, J.
    A formal total synthesis of (–)-brevisamide
    Tetrahedron Lett. 2011, 52, 2117-2119.
  8. Ohyoshi, T.; Miyazawa, Y.; Aoki, K.; Ohmura, S.; Asuma, Y.; Hayakawa, I.; Kigoshi, H.
    Synthetic Studies toward 13-Oxyingenol: Construction of the Fully Substituted Tetracyclic Compound
    Org. Lett. 2011, 13, 2160-2163.
  9. Miyata, Y.; Fujii, H.; Osa, Y.; Kobayashi, S.; Takeuchi, T.; Nagase, H.
    Opioid δ1 receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chliroquine-resistant Plasmodium chabaudi
    Bioorg. Med. Chem. Lett. 2011, 21, 4710-4712.
  10. Nagase, H.; Koyano, K.; Wada, N.; Hirayama, S.; Watanabe, A.; Nemoto, T.; Nakajima, M.; Nakao, K.; Mochizuki, H.; Fujii, H.
    Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 2, synthesis of novel triplet drugs with epoxyethano-structure (capped homotriplet)
    Bioorg. Med. Chem. Lett. 2011, 21, 6198-6202.
  11. Enomoto, T.; Yamashita, A.; Torigoe, K.; Horiuchi, H.; Hirayama, S.; Nakahara, K.; Yanase, M.; Sakai, H.; Ikegami, D.; Nagase, H.; Suzuki, T.; Iseki, M.; Inada, E.; Narita, M.
    Effects of mirtazapine on sleep disturbance underneuropathipain-like state
    Synapse 2011, 21532.
  12. Saito, T.; Ogawa, S.; Takei, N.; Kutsumura, N.; Otani, T.
    Palladium-Catalyzed Highly Regio- and Stereoselective Synthesis of 4-Alkylidene-4H-3,1-benzoxazines from N-Acyl-o-alkynylanilines
    Org. Lett. 2011, 13, 1098-1101.
  13. Hayakawa, I.; Miyazawa, Y.; Ohyoshi, T.; Asuma, Y.; Aoki, K.; Kigoshi, H.
    Synthetic studies toward optically active 13-oxyingenol via asymmetric cyclopropanation
    Synthesis 2011, 769-777.
  14. Nagase, H.; Watanabe, A.; Nemoto, T.; Nakajima, M.; Hasebe, K.; Mochizuki, H.; Fujii, H.
    Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons
    Bioorg. Med. Chem. Lett. 2011, 21, 4023-4026.
  15. Hayashida, K.; Fujii, H.; Hirayama, S.; Nemoto, T.; Nagase, H.
    Rearrangement of 4,5 – α-Epoxymorphinan Derivatives With Carbamoylepoxy Rings Provide Novel Oxazatricyclodecane Structures
    Tetrahedron 2011, 67, 6682-6688.
  16. Nemoto, T.; Yamamoto, N.; Watanabe, A.; Fujii, H.; Hasebe, K.; Nakajima, M.; Mochizuki, H.; Nagase, H.
    Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies
    Bioorg. Med. Chem. 2011, 19, 1205-1221.
  17. Yamamoto, N.; Fujii, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Inokoshi, J.; Tomoda, H.; Nagase, H.
    Synthesis of (–)-homogalanthamine from naltrexone
    J. Org. Chem. 2011, 76, 2257-2260.

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筑波大学WPI-IIIS長瀬研究室(創薬化学)では、オレキシン作動薬の開発や、オピオイドの研究を行っています。

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