筑波大学WPI-IIIS長瀬研究室(創薬化学)では、オレキシン作動薬の開発やオピオイドの研究を行っています。

2012 Original Papers / 2012 原著論文

  1. Hara, A.; Morimoto, R.; Iwasaki, Y.; Saitoh, T.; Ishikawa, Y.; Nishiyama, S.
    Total Syntheses of Amphidinolides B, G, and H
    Angew. Chem. Int. Ed. 2012, 51, 9877-9880.
  2. Fujii, H.; Nakajima, R.; Akiyama, J.; Yamamoto, N.; Hirayama, S.; Nemoto, T.; Gouda, H.; Hirono, S.; Nagase, H.
    Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
    Bioorg. Med. Chem. Lett. 2012, 21, 7697-7701.
  3. Nakano, H.; Kutsumura, N.; Saito, T.
    Functionalized Carbodiimide Mediated Synthesis of 2,3-Disubstituted Quinazolin-4(3H)-ones via the Tandem Strategy of C-Nucleophilic Addition and Intramolecular NH-Substitution Cyclization
    Synthesis 2012, 44, 3179-3184.
  4. Kajiyama, D.; Saitoh, T.; Yamaguchi, S.; Nishiyama, S.
    Oxidative Cyclization of Tryptamine by means of Hypervalent Iodobenzene toward Pyrroloindole Alkaloid Synthesis
    Synthesis 2012, 44, 1667-1671.
  5. Nagase, H.; Akiyama, J.; Nakajima, R.; Hirayama, S.; Nemoto, T.; Gouda, H.; Hirono, S.; Fujii, H.
    Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain
    Bioorg. Med. Chem. Lett. 2012, 22, 2775-2779.
  6. Kutsumura, N.; Kiriseko, A.; Saito, T.
    Total Synthesis of (+)-Heteroplexisolide E
    Heterocycles 2012, 86, 1367-1378.
  7. Fujii, H.; Yamada, T.; Hayashida, K.; Kuwada, M.; Hamasaki, A.; Nobuhara, K.; Ozeki, S.; Nagase, H.
    Application of SO3H Silica gel to Deprotection of Silyl Ethers
    Heterocycles 2012, 85, 2685-2691.
  8. Sumi, T.; Saitoh, T.; Natsui, K.; Yamamoto, T.; Atobe, M.; Einaga, Y.; Nishiyama, S.
    Anodic oxidation on a boron-doped diamond electrode mediated by methoxy radicals
    Angew. Chem. Int. Ed. 2012, 51, 5443-5446.
  9. Ohyoshi, T.; Funakubo, S.; Miyazawa, Y.; Niida, K.; Hayakawa, I.; Kigoshi, H.
    Total Synthesis of (–)-13-Oxyingenol and its Natural Derivative
    Angew. Chem. Int. Ed. 2012, 51, 4972-4975.
  10. Ida, Y.; Matsubara, A.; Nemoto, T.; Saito, M.; Hirayama, S.; Fujii, H.; Nagase, H.
    Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands
    Bioorg. Med. Chem. 2012, 20, 5810-5831.
  11. Kutsumura, N.; Kiriseko, A.; Saito, T.
    First total synthesis of (+)-heteroplexisolide E
    Tetrahedron Lett. 2012, 53, 3274-3276.
  12. Fujii, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Gouda, H.; Hirono, S.; Nagase, H.
    Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthorene derivatives with an oxygen functionality at the 3-position and their pharmacologies
    Bioorg. Med. Chem. Lett. 2012, 22, 7711-7714.
  13. Wada, N,; Fujii, H.; Koyano, K.; Hirayama, S.; Iwai, T.; Nemoto, T.; Nagase, H.
    Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)
    Bioorg. Med. Chem. Lett. 2012, 22, 7551-7554.
  14. Miyata, Y.; Fujii, H.; Uenohara, Y.; Kobayashi, S.; Takeuchi, T.; Nagase, H.
    Investigation of 7-benzylidenenaltrexone derivatives as reverser of resitance for chliroquine-resistant Plasmodium chabaudi
    Bioorg. Med. Chem. Lett. 2012, 22, 5174-5176.
  15. Honda, T.; Arai, H.; Yamamoto, N.; Takahashi, K.
    Formal synthesis of sceletium alkaloids, (±)-mesembrine and (±)-mesembranol
    Heterocycles 2012, 84, 327-331.
  16. Saito, T.; Nakano, H.; Terada, H.; Kutsumura, N.; Otani, T.
    Expedient Synthesis of 3,4-Dihydro-quinazolines via Tandem Addition―Conjugate Addition Cyclization of Carbodiimides Bearing a Michael Acceptor
    Heterocycles 2012, 84, 893-911.
  17. Nagase, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Fujii, H.
    Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: Synthesis of decahydroiminoethano)phenanthoren derivatives and their pharmacologies
    Bioorg. Med. Chem. Lett. 2012, 22, 5071-5074.
  18. Al-Mekhlafi, N. A.; Shaari, K.; Abas, F.; Kneer, R.; Jeyaraj, E. J.; Stanslas, J.; Yamamoto, N.; Honda, T.; Lajis, N. H.
    Alkenylresorcinols and cytotoxic activity of the constituents isolated from Labisia pumila
    Phytochemistry 2012, 80, 42-49.
  19. Nagase, H.; Imaide, S.; Yamada, T.; Hirayama, S.; Nemoto, T.; Yamaotsu, N.; Hirono, S.; Fujii, H.
    Essential Structure of Opioid κ Receptor Agonist Nalfurafine for Binding to κ Receptor 1: Synthesis of Decahydroisoquinoline Derivatives and Their Pharmacologies
    Chem. Pharm. Bull. 2012, 60, 945-948.
  20. Watanabe, Y.; Kitazawa, S.; Fujii, H.; Nemoto, T.; Hirayama, S.; Nagase, H.
    Design and synthesis of novel opioid ligands with anazabicyclo[2.2.2]octane skeleton and their pharmacologies
    Bioorg. Med. Chem. 2012, 22, 2689-2692.
  21. Ida, Y.; Nemoto, T.; Hirayama, S.; Fujii, H.; Osa, Y.; Imai, M.; Nakamura, T.; Kanemasa, T.; Kato, T.; Nagase, H.
    Synthesis of quinolinomorphinan-4-ol derivatives as delta opioid receptor agonist
    Bioorg. Med. Chem. 2012, 20, 949-961.
  22. Torigoe, K.; Nakahara, K.; Rahmadi, M.; Yoshizawa, K.; Horiuchi, H.; Hirayama, S.; Imai, S.; Kuzumaki, N.; Ito, T.; Yamashita, T.; Shakunaga, K.; Yamasaki, M.; Nagase, H.; Matoba, M.; Suzuki, T.; Narita, M.
    Usefulness of Olanzapine as an Adjunct to Opioid Treatment and for the Treatment of Neuropathic pain
    Anesthesiology 2012, 116, 159-169.
  23. Tanahashi, S.; Ueda, Y.; Yamamura, S.; Nagase, H.; Okada, M.
    Novel δ 1-receptor agonist KNT-127 increases releases of dopamine and L-Glutamate in striatum, nucleus accumbens and median prefrontal cortex
    Neurpharmacology 2012, 62, 2057-2067.
  24. Kuzumaki, N,; Suzuki, A.; Narita, M.; Hosoya, T.; Nagasawa, A.; Imai, S.; Yamamizu, K.; Morita, H.; Nagase, H.; Okada, Y.; Okano, H. J.; Yamashita, J. K.; Okano, H.; Suzuki, T.; Narita, M.
    Effect of κ-opioid, receptor agonist on the growth of non-small-cell lung cancer (NSCLC) cells
    British J. Cancer 2012, 106, 1148-1152.

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筑波大学WPI-IIIS長瀬研究室(創薬化学)では、オレキシン作動薬の開発や、オピオイドの研究を行っています。

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