筑波大学WPI-IIIS長瀬研究室(創薬化学)では、オレキシン作動薬の開発やオピオイドの研究を行っています。

2013 Original Papers / 2013 原著論文

  1. Yamamizu, K.; Furuta, S.; Hamada, Y.; Yamashita, A.; Kuzumaki, N.; Narita, M.; Doi, K.; Katayama, S.; Nagase, H.; Yamashita, J. K.; Narita, M.
    “κ Opioids inhibit tumor angiogenesis by suppressing VEGF signaling”
    Scientific Reports 2013, 3: 3213. (web)
  2. Nemoto, T.; Ida, Y.; Iihara, Y.; Nakajima, R.; Hirayama, S.; Iwai, T.; Fujii, H.; Nagase, H.
    “The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists”
    Bioorg. Med. Chem. 201321, 7628-7647. (web)
  3. Kawa, K.; Saitoh, T.; Kaji, E.; Nishiyama, S.
    “Development of Glycosylation Using the Glucopyranose 1,2-Orthobenzoate under Electrochemical Conditions”
    Org. Lett. 2013, 15, 5484-5487. (web)
  4. Kuroda, M.; Funasaki, S.; Saitoh, T.; Sasazawa, Y.; Nishiyama, S.; Umezawa, K.; Shimizu, S.
    “Determination of topological structure of ARL6ip1 in cells: Identification of the essential binding region of ARL6ip1 for conophylline”
    FEBS Letters 2013, 587, 3656-3660. (web)
  5. Watanabe, Y.; Kitazawa, S.; Nemoto, T.; Hirayama, S.; Iwai, T.; Fujii, H.; Nagase, H.
    “Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide chain and their pharmacologies”
    Bioorg. Med. Chem. 2013, 21, 3032-3050. (web)
  6. Kajiyama, D.; Saitoh, T.; Yamaguchi, S.; Nishiyama, S.
    “Application of the Hypervalent Iodine Oxidant Electrochemically Generated to Natural Products Synthesis”
    Electrochemistry 2013, 81, 319-324. (web)
  7. Kutsumura, N.; Matsubara, Y.; Niwa, K.; Ito, A.; Saito, T.
    “Novel One-pot Method for Regioselective Bromination and Sequential Carbon−Carbon Bond-forming Reactions of Allylic Alcohol Derivatives”
    Eur. J. Org. Chem. 2013, 3337-3346. (web)
  8. Ise, Y.; Mori, T.; Katayama, S.; Nagase, H.; Suzuki, T.
    “Rewarding effects of ethanol combined with low doses of morphine through dopamine D1 receptor”
    J. Nippon Medical School 2013, 80, 34-41. (web)
  9. Otani, T.; Saito, T.; Sakamoto, R.; Osada, H.; Hirahara, A.; Furukawa, N.; Kutsumura, N.; Matsuo, T.; Tamao, K.
    “Intramolecular [2+2+2] cycloaddition of bis(propargylphenyl)carbodiimides: synthesis of L-shaped π-extended compounds with pyrrolo[1,2-a][1,8]naphthyridine corner units”
    Chem. Commun. 2013, 49, 6206-6208. (web)
  10. Saitoh, A.; Sugiyama, A.; Yamada, M.; Inagaki, M.; Oka, J.; Nagase, H.; Yamada, M.
    “The novel δ opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepines”
    Neuropharmacology 2013, 67, 485-493. (web)
  11. Nemoto, T.; Yamamoto, N.; Wada, N.; Harada, Y.; Tomatsu, M.; Ishihara, M.; Hirayama, S.; Iwai, T.; Fujii, H.; Nagase, H.
    “The effect of 17-N substituents on the activity of the opioid kappa receptor in nalfurafine derivatives”
    Bioorg. Med. Chem. Lett. 2013, 23, 268-272. (web)

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筑波大学WPI-IIIS長瀬研究室(創薬化学)では、オレキシン作動薬の開発や、オピオイドの研究を行っています。

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