筑波大学WPI-IIIS長瀬研究室(創薬化学)では、オレキシン作動薬の開発やオピオイドの研究を行っています。

2015 Original Papers / 2015 原著論文

  1. Nagahara, T.; Saitoh, T.; Kutsumura, N.; Irukayama-Tomobe, Y.; Ogawa, Y.; Kuroda, D.; Gouda, H.; Kumagai, H.; Fujii, H.; Yanagisawa, M.; Nagase, H.
    “Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists”
    J. Med. Chem. 2015, 58, 7931-7937. (web)  - Featured Article -
    Most Read Article (Sep. 2015)
  2. Nakajima, R.; Yamamoto, N.; Hirayama, S.; Iwai, T.; Saitoh, A.; Nagumo, Y.; Fujii, H.; Nagase, H.
    “Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain”
    Bioorg. Med. Chem. 2015, 23, 6271-6279. (web)
  3. Kutsumura, N.; Nakajima, R.; Koyama, Y.; Miyata, Y.; Saitoh, T.; Yamamoto, N.; Iwata, S.; Fujii, H.; Nagase, H.
    “Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound”
    Bioorg. Med. Chem. Lett. 2015, 25, 4890-4892. (web)
  4. Kobayashi, S.; Kudo, K.; Ito, A.; Honjo, T.; Yata, M.; Otani, T.; Kutsumura, N.; Saito, T.; Berrée, F.; Romain, E.; Tripoteau, F.; Carboni, B.
    “[3]-1-Azadendralenes as Versatile Building Blocks for the Stereoselective Synthesis of Polysubstituted Hexahydroquinazolin-2-ones and Hexahydrobenzothiazine-2-imines”
    Eur. J. Org. Chem. 2015, 4367-4373. (web)
  5. Ikeda, H.; Ardianto, C.; Yonemochi, N.; Yang, L.; Ohashi, T.; Ikegami, M.; Nagase, H.; Kamei, J.
    “INHIBITION OF OPIOID SYSTEMS IN THE HYPOTHALAMUS AS WELL AS THE MESOLIMBIC AREA SUPPRESSES FEEDING BEHAVIOR OF MICE”
    Neuroscience 2015, 311, 9-21. (web)
  6. Kutsumura, N.; Matsuo, K.; Saito, T.
    “Total synthesis of aplysinoplide B”
    Tetrahedron Lett. 2015, 56, 2602-2604. (web)
  7. Kutsumura, N.; Inagaki, M.; Kiriseko, A.; Saito, T.
    “Novel One-pot Synthetic Method for Propargyl Alcohol Derivatives from Allyl Alcohol Derivatives”
    Synthesis 2015, 47, 1844-1850. (web)
  8. Kutsumura, N.; Matsubara, Y.; Honjo, T.; Ohgiya, T.; Nishiyama, S.; Saito, T.
    “Total Synthesis of (―)-5,6-seco-Germacrane Lactone”
    Tetrahedron 2015, 71, 2382-2386. (web)
  9. Otani, T.; Jiang, X.; Cho, K.; Araki, R.; Kutsumura, N.; Saito, T.
    “Lewis Acid-Catalyzed or Base-Promoted Regioselective Cycloisomerization of N-Imidoyl-o-alkynylanilines for Synthesis of N-Imidoyl-(1H)-indoles and 4-Alkylidene-3,4-dihydroquinazolines”
    Adv. Synth. Catal. 2015, 357, 1483-1492. (web)
  10. Suzuki, M.; Chiwaki, F.; Sawada, Y.; Ashikawa, M.; Aoyagi, K.; Fujita, T.; Yanagihara, K.; Komatsu, M.; Narita, M.; Suzuki, T.; Nagase, H.; Kushima, R.; Sakamoto, H.; Fukagawa, T.; Katai, H.; Nakagama, H.; Yoshida, T.; Uezono, Y.; Sakaki, H.
    “Peripheral Opioid Antagonist Enhances the Effect of Anti-Tumor Drug by Blocking a Cell Growth-Suppressive Pathway In Vivo
    PLoS One 2015, 10, e0123407. (web)
  11. Nemoto, T.; Iihara, Y.; Hirayama, S.; Iwai, T.; Higashi, E.; Fujii, H.; Nagase, H.
    “Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists”
    Bioorg. Med. Chem. Lett. 2015, 25, 2927-2930. (web)
  12. Konoura, K.; Fujii, H.; Imaide, S.; Gouda, H.; Hirayama, S.; Hirono, S.; Nagase, H.
    “Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors”
    Bioorg. Med. Chem.  201523, 439-448. (web)

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筑波大学WPI-IIIS長瀬研究室(創薬化学)では、オレキシン作動薬の開発や、オピオイドの研究を行っています。

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